In the early 90s triptans became the new wonder drug for treating migraines. They became quite the migraine revolution and have since helped a huge number of migraine sufferers. Now scientists believe they may have found the next class of wonder drugs to help migraine sufferers. Move over triptans, the anti-CGRPs are here.
CGRP treatments works by blocking the activity of a molecule called calcitonin gene-related peptide (hence the drug’s name), a molecule which is significantly increased during a migraine attack. Currently four pharmaceutical companies are in the process of completing advanced trials of CGRP targeting medications that neutralise or block the CGRP and data from the trials suggests that, for some sufferers, they could be an effective long-term solution.
Dr David Dodick, a neurologist at the Mayo Clinic in Phoenix in the U.S., has said that for “superresponders”, migraine attacks completely disappeared for a massive six months after one injection of a CGRP-blocking antibody. He went on to say that; “I’ve been in this field now for 21 years, and this is the most exciting thing we’ve seen so far.” However, more studies will have to be done before it’s efficacy can be judged completely.
It won’t be for everyone, but for some migraine sufferers out there, anti-CGRP treatments can’t come fast enough.
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